Sodium Polystyrene Sulfonate is a non-absorbed, cation exchange polymer that contains a sodium counterion. Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F) [see USP Controlled Room Temperature], Distributed by Alexso, Inc. Los Angeles, CA 90064, sodium bicarbonate, Kayexalate, insulin regular, calcium gluconate, Humulin R, Veltassa. Do not use potassium supplements, calcium supplements, or salt substitutes while you are taking sodium polystyrene sulfonate, unless your doctor has told you to. Polystyrene sulfonates are a group of medications used to treat high blood potassium. Select all that apply. Oral:15 g orally once a dayMaximum dose: 15 g orally 4 times a dayComments:-A 15 g dose is equivalent to approximately 4 level teaspoons.-This drug should be given as a suspension in water or syrup (not fruit juice).Rectal:30 g rectally every 6 hoursMaximum dose: 50 g rectally every 6 hoursComments:-This drug should be administered via warm emulsion in 100 mL of aqueous vehicle.-This solution should be gently agitated during administration.-The enema should be retained as long as possible and should be followed by a cleansing enema.Use: Treatment of hyperkalemia, Calculate dose based on 1 mEq potassium per 1 g resinComment:-A 15 g dose is equivalent to approximately 4 level teaspoons.-This drug should be given as a suspension in water or syrup (not fruit juice).-The oral route should be avoided in neonates.Use: Treatment of hyperkalemia. Do not use the medicine orally or rectally in a baby who has slow digestion caused by surgery or by using other medicines. Cases of acute bronchitis or bronchopneumonia caused by inhalation of Sodium Polystyrene Sulfonate particles have been reported. A low serum potassi-um concentration indicates disruption of normal homeostasis, with one very rare exception. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. This action occurs primarily in the large intestine, which excretes potassium ions to a greater degree than does the small intestine. Medically reviewed by Drugs.com. Store at room temperature away from moisture and heat. Agitate the emulsion gently during administration. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. The rectal enema form of this medicine is usually given by a healthcare professional. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If necessary, sodium polystyrene sulfonate may be administered into the stomach through a plastic tube. Uses; Before taking; Warnings; Dosage; Side effects; Storage; Uses of Sodium Polystyrene Sulfonate Powder: Hypersensitivity to polystyrene sulfonate resins, The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an, Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F), Sodium Polystyrene Sulfonate powder, for suspension, We comply with the HONcode standard for trustworthy health information -. A client has a prescription to take sodium polystyrene sulfonate for several days. Available for Android and iOS devices. Advise patients who are taking other oral medication to separate the dosing of Sodium Polystyrene Sulfonate by at least 3 hours (before or after) [see Dosage and Administration (2.1), Warnings and Precautions (5.5), and Drug Interactions (7.1)]. Sodium content approximately 60 mEq per 15 g. Suspension should be freshly prepared and not stored beyond 24 hours. Administered as an oral suspension, sodium polystyrene sulfonate lowers serum potassium levels by exchanging its sodium ions for potassium ions. The effect must be carefully controlled by frequent serum potassium determinations within each 24 hour period. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Sodium Polystyrene Sulfonate is available as a cream to light brown, finely ground powder in jars of 1 pound (453.6 g), NDC 50488-5001-1. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels. ECI Pharmaceuticals, LLC Fort Lauderdale, FL 33309. Drug classes. Too much potassium in your blood can sometimes cause heart rhythm problems. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an exchange capacity of approximately 3.1 mEq (approximately 1 mEq) of potassium per gram. Sodium Polystyrene Sulfonate is not totally selective for potassium, and small amounts of other cations such as magnesium and calcium can also be lost during treatment. Sodium polystyrene sulfonate may also be used for purposes not listed in this medication guide. The effective lowering of serum potassium with Sodium Polystyrene Sulfonate may take hours to days. Avoid using antacids or laxatives without your doctor's advice. Use the medicine exactly as directed. Discontinue use in patients who develop constipation. KAYEXALATE (sodium polystyrene sulfonate) is a cream or light brown fine powder of sodium polystyrene sulfonate. Select one or more newsletters to continue. The practical exchange ratio is 1 mEq K per 1 gram of resin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Oral. Keep using this medicine even if you feel fine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. The efficiency of this process is limited and unpredictably variable. The average adult dose is 30 g to 50 g every six hours. Limitation of Use: Sodium Polystyrene Sulfonate should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. sodium polystyrene sulfonate) Administration of IV Insulin-Glucose, and inhaled beta-agonists (albuterol) IV Calcium administration to prevent cardiac arrythmias. The following adverse reactions are discussed elsewhere in the labeling: The following adverse reactions have been identified during post-approval use of Sodium Polystyrene Sulfonate. Sodium Polystyrene Sulfonate Powder. Do not use two doses at one time. The latest research on Global Sodium Polystyrene Sulfonate Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 comprises a fully comprehensive assessment of the industry vertical and highlights the various market segmentation. As the resin passes along the intestine or is retained in the colon after administration by enema, the sodium ions are partially released and are replaced by potassium ions. Do not heat Sodium Polystyrene Sulfonate as it could alter the exchange properties of the resin. Patients with gastroparesis may require a 6 hour separation [see Warnings and Precautions (5.5) and Drug Interaction (7)]. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia. Ensure an adequate volume of cleansing solution (up to 2 liters) is utilized. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. In pediatric patients, as in adults, Sodium Polystyrene Sulfonate is expected to bind potassium at the practical exchange ratio of 1mEq potassium per 1 gram of resin. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or establish a causal relationship to drug exposure. We comply with the HONcode standard for trustworthy health information -, Sodium polystyrene sulfonate side effects, Detailed Sodium polystyrene sulfonate dosage information, Sodium polystyrene sulfonate drug interactions. Sodium polystyrene sulfonate, USP is a cream to light brown, finely ground powder and is available in 454 g jars and 15 g bottles. Appropriate measures should be taken to correct serum electrolytes (potassium, calcium, magnesium), and the resin should be removed from the alimentary tract by appropriate use of laxatives or enemas. Exchange Resin (About this - PubMed Health) Uses Uses of This Medicine Sodium Polystyrene Sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram. Call your doctor for medical advice about side effects. You should not use sodium polystyrene sulfonate if you are allergic to it, or if you have: a weak immune system caused using certain medicine; severe constipation or other bowel problems; kidney disease (or if you are on dialysis); an electrolyte imbalance (such as low levels of potassium, calcium, or magnesium in your blood); a bowel disorder, or surgery on your intestines; Because sodium polystyrene sulfonate is not absorbed into the bloodstream, this medicine is not expected to be harmful during pregnancy or while nursing a baby. Adjustment of other sources of sodium may be required. The report evaluates the opportunities and current market scenario, providing insights and updates about the … It works by removing excess potassium from the body. Last updated on Dec 1, 2019. Cabbage Mushrooms Strawberries. Avoid eating or drinking anything that contains sorbitol (a fruit sugar often used as a sweetener in chewing gum, diet drinks, baked goods, or frozen desserts). Sodium Polystyrene Sulfonate increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. Patients with gastroparesis may require a 6 hour separation. In neonates, Sodium Polystyrene Sulfonate should not be given by the oral route. In vitro binding studies showed that Sodium Polystyrene Sulfonate bound significantly to the following tested drugs – warfarin, metoprolol, phenytoin, furosemide, amlodipine and amoxicillin. Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F) [see USP Controlled Room Temperature]. Gastrointestinal: anorexia, constipation, diarrhea, fecal impaction, gastrointestinal concretions (bezoars), ischemic colitis, nausea, ulcerations, vomiting, gastric irritation, intestinal obstruction (due to concentration of aluminium hydroxide). signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Concomitant administration of sorbitol is not recommended. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You may need to hold in the enema for up to several hours. Schedule your appointment now for safe in-person care. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Drug Interactions. Sodium polystyrene sulfonate is a cation-exchange resin taken orally that is used to reduce high levels of potassium in the blood (hyperkalemia). Antacids or laxatives can make sodium polystyrene sulfonate less effective, or cause serious side effects. Sodium polystyrene sulfonate binds itself to potassium in your digestive tract. In addition to lowering average potassium content by 65%, the calcium content of breastmilk was reduced by 84%. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. The sodium content is approximately 4.1 mmol Copyright 1996-2021 Cerner Multum, Inc. Sodium Polystyrene Sulfonate is not absorbed systemically by the mother, so breastfeeding is not expected to result in risk to the infant. One gram of Sodium Polystyrene Sulfonate contains 4.1 mEq of sodium. Sodium polystyrene sulfonate for suspension is available as a golden brown, finely ground powder in jars of 1 pound (454 g), NDC 11534-166-44, in bottles of 15 g, NDC 11534-166-16 and 10 in 1... 17 PATIENT COUNSELING INFORMATION Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Sodium Polystyrene Sulfonate is not absorbed systemically following oral or rectal administration and maternal use is not expected to result in fetal risk. Do not mix the powder with any juice or other liquid that contains potassium, such as orange juice. Sorbitol may contribute to the risk of intestinal necrosis [see Warnings and Precautions (5.1)] and concomitant use is not recommended. Tell your doctor if you are pregnant or breast-feeding. Which foods should the client avoid? Avoid use in patients who have not had a bowel movement post-surgery. Too much potassium in your blood can sometimes cause heart rhythm problems. B. Hyperphosphatemia and Hypocalcemia Intravenous hydration and continuous telemetry Frequent monitoring of serum phosphate and The enema will be inserted slowly while you are lying down. Follow your doctor's orders or the directions on the label. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. Written by Cerner Multum. Generic Name: sodium polystyrene sulfonate (SOE dee um pol ee STEER een SUL foe nate)Brand Name: Kalexate, Kayexalate, KionexDosage Forms: oral and rectal powder (-); oral and rectal suspension (15 g/60 mL). Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. Stop using sodium polystyrene sulfonate and call your doctor at once if you have: severe constipation, severe stomach pain, bloating; confusion, thinking problems, feeling irritable; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or. Patients with impaired gag reflex, altered level of consciousness, or patients prone to regurgitation may be at increased risk. This medicine may be used for other purposes; ask your health care provider or … Generic Name: Sodium Polystyrene Sulfonate Powder (SOE dee um POL ee STYE reen SUL foe nate) Brand Name: Kayexalate, Kionex. Monitor serum potassium during therapy because severe hypokalemia may occur. The amount of medicine that you take depends on the strength of the medicine. Sodium Polystyrene Sulfonate is a potassium ion exchange resin composed of benzene -diethyl polymer with ethenyl-benzene, sulfonated, sodium salt. Before Using Sodium Polystyrene Sulfonate Suspension USP (SPS® Suspension) can be administered orally or in an enema. The sodium polystyrene sulfonate enema is usually followed with a second cleansing enema. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Effects generally take hours to days. 41688 Poly(styrene sulfonic acid) sodium salt, M.W. It can be administered orally or rectally as an enema. Monitor patients who are sensitive to sodium intake (heart failure, hypertension, edema) for signs of fluid overload. Last updated on Oct 23, 2020. Administer with patient in an upright position [see Warnings and Precautions (5.4)]. Applies to sodium polystyrene sulfonate: oral or rectal powder for suspension, oral or rectal suspension Side effects include: Gastric irritation, anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), nausea, vomiting, hypokalemia, hypocalcemia, hypomagnesemia, clinically important sodium retention. Decreased absorption of lithium and thyroxine have also been reported with co-administration of Sodium Polystyrene Sulfonate. A somewhat thicker suspension may be used, but do not form a paste. The majority of these cases reported the concomitant use of sorbitol. Follow all directions on your prescription label and read all medication guides or instruction sheets. in vitro. Sodium polystyrene sulfonate is in a class of medications called potassium-removing agents. Dispense in tight, light-resistant containers as defined in the official compendia. Prepare suspension fresh and use within 24 hours. Sodium polystyrene sulfonate is a cream to light brown, finely ground powder and is available in 453.6 g jars. Sodium Polystyrene Sulfonate is contraindicated in patients with the following conditions: Cases of intestinal necrosis, some fatal, and other serious gastrointestinal adverse events (bleeding, ischemic colitis, perforation) have been reported in association with Sodium Polystyrene Sulfonate use. If you have a condition that slows your digestion, avoid taking other medicines by mouth within 6 hours before or 6 hours after you take sodium polystyrene sulfonate. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. KAYEXALATE is a cation-exchange resin prepared in the sodium phase, with an in vivo exchange capacity of approximately 1 mmol (in vitro approximately 3.1 mmol) of potassium per gram. Sodium polystyrene sulfonate works differently from other medicines because it … Administer other oral medications at least 3 hours before or 3 hours after Sodium Polystyrene Sulfonate. In some Use only in patients who have normal bowel function. You may report side effects to FDA at 1-800-FDA-1088. The simultaneous oral administration of Sodium Polystyrene Sulfonate with nonabsorbable cation- donating antacids and laxatives may reduce the resin's potassium exchange capability and increase the risk of systemic alkalosis. Do not give this medicine orally (by mouth) to a newborn baby. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Monitor calcium and magnesium in patients receiving Sodium Polystyrene Sulfonate. CAS Number. SODIUM POLYSTYRENE SULFONATE takes potassium out of the body by binding to it in the intestines. It is used to treat too much potassium in the body. 25704-18-1. exchange Medically reviewed by Drugs.com. Administer Sodium Polystyrene Sulfonate with the patient in an upright position. This can apply to medicines that should be used only for certain medical conditions or are more costly than other drugs proven to be just as effective. It is used to treat too much potassium in the body. Other drugs may affect sodium polystyrene sulfonate, including prescription and over-the-counter medicines, vitamins, and herbal products. No formal drug interaction studies have been conducted in humans. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Hyperkalemia often has no symptoms that you will notice until your potassium levels are very low. One level teaspoon contains approximately 3.5 g of Sodium Polystyrene Sulfonate and 15 mEq of sodium. Use the HNE Drug Lookup to find the prescription drugs that we consider medically appropriate and cost effective to keep health care affordable for everyone.. Is your drug covered? Hemodialysis or hemofiltration. This medicine is available only with your doctor's prescription. KAYEXALATE, brand of sodium polystyrene sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an . The following information includes only the average doses of this medicine. Select one or more newsletters to continue. Sodium polystyrene sulfonate removes potassium by exchanging sodium ions for potassium ions in the intestine. They are also used to remove potassium, calcium, and sodium from solutions in technical applications. Don't delay your care at Mayo Clinic. This medication is used to treat a high level of potassium in your blood. After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place. [1] Avoid use in patients who are at risk for developing constipation or impaction (including those with history of impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, or bowel obstruction). Sodium polystyrene sulfonate binds to many commonly prescribed oral medicines, decreasing the absorption and therefore the effectiveness of those oral medicines. Sodium Polystyrene Sulfonate is not absorbed systemically. Avoid taking other medicines by mouth within 3 hours before or 3 hours after you take sodium polystyrene sulfonate (or 6 hours before/after if you have slow digestion). Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Avoid inhaling the oral powder while you are preparing a dose. Not all possible drug interactions are listed here. See complete prescribing information. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem f… Sodium polystyrene sulfonate can make it harder for your body to absorb medicines you take by mouth. The dose of this medicine will be different for different patients. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. This helps prevent your body from absorbing too much potassium. pressure when sodium intake is not restricted, pre-sumably by promoting renal sodium retention. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sodium Polystyrene Sulfonate (By mouth) SOE-dee-um pol-ee-STYE-reen SUL-foe-nate. Polymer molecular weights were in the range 1.5 ≤ M ≤ 1188 kDa; solvents were in the high-salt (0.2M NaCl) regime. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. In in vitro binding studies, Sodium Polystyrene Sulfonate was shown to significantly bind the oral medications (n=6) that were tested. Sodium Polystyrene Sulfonate has the potential to bind other drugs. Overdosage may result in electrolyte disturbances including hypokalemia, hypocalcemia, and hypomagnesemia. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Average adult dose: 15 g (approximately 4 level Teaspoons) one to four times daily in water. Monitor for clinical response and/or blood levels where possible. 16 Hypokalemia is rarely suspected on the basis of clinical presentation; the diagnosis is made by meas-urement of serum potassium. Sodium Polystyrene Sulfonate may bind orally administered medications, which could decrease their gastrointestinal absorption and lead to reduced efficacy. This list is not complete. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. A suspension of sodium polystyrene sulfonate has been added directly to breastmilk to lower the potassium concentration of milk for use in infants with renal impairment. Binding of Sodium Polystyrene Sulfonate to other oral medications could cause decreased gastrointestinal absorption and loss of efficacy when taken close to the time Sodium Polystyrene Sulfonate is administered. Administer Sodium Polystyrene Sulfonate at least 3 hours before or 3 hours after other oral medications. Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Administer as a warm (body temperature) emulsion in 100 mL of aqueous vehicle and flush with 50 to 100 ml of fluid. Some drugs may have to be approved before the plan covers them. Premature infants or low birth weight infants may have an increased risk for gastrointestinal adverse effects with Sodium Polystyrene Sulfonate use [see Warnings and Precautions (5.4)]. Patients with gastroparesis may require a 6 hour separation. To give this medicine orally: Mix the sodium polystyrene sulfonate powder with water, or with honey or jam to make it taste better. For non-prescription products, read the label or package ingredients carefully.

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