Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. Desmin is the major intermediate filament (IF) protein in human heart and skeletal muscle. Der Seulinger ist seit fast acht Jahren hauptamtlicher Bürgermeister, politisch engagiert er sich aber schon wesentlich länger: Vor 30 Jahren trat er in die SPD ein und wurde schnell in den Seulinger Gemeinderat gewählt. Finde 12 Profile von Wolfgang Link mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING. Sein weiterer Weg führte Wolfgang Pauli an die Universität Göttingen, die eine langjährige Tradition als Hochburg der Mathematik aufwies. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. Fraktion Göttinger Linke Neues Rathaus, Zi. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. All rights reserved. The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells, where it determines passive tension development and modul... Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. Working Group "Breeding Research Faba Bean" Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. 207 likes. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart, Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator, Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function, A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues, Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D, The Specific Cleavage of Titin Springs to Quantify the Contribution of Titin to Myocardial Passive Stiffness, Erratum: Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis, Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients, Symmetric dimethylarginine in dysfunctional high-density lipoprotein mediates endothelial glycocalyx breakdown in chronic kidney disease, Funktionelle Analyse zweier neuer Desmin-Mutationen, assoziiert mit familiären Kardiomyopathien, Arrhythmien und einem erhöhten Risiko für plötzlichen Herztod, Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function, P.78Sarcomeric pathology induced by homozygous expression of the myofibrillar myopathy - associated p.W2711X filamin C mutant, P.80Imbalances in protein homeostasis caused by mutant desmin, Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis, Abstract 330: A HaloTag-TEV Genetic Cassette for Mechanically Probing Native Titin, Abstract 466: Myopathy Causing Bag3 P209L Protein Leads to Restrictive Cardiomyopathy Caused by Aggregate Formation and Sarcomere Disruption in Cardiomyocytes, Cardiac α-Actin ( ACTC1 ) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy, The Translational Landscape of the Human Heart, Sarkomerische Pathologie durch die homozygote Expression der Myofibrilläre Myopathie-assoziierten W2711X Filamin-C Mutante, Mutiertes Desmin verursacht komplexe Störungen der muskulären Proteinhomeostase, The continuous heart failure spectrum: Moving beyond an ejection fraction classification. Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Left atrial (LA) compliance and contractility influence left ventricular stroke volume. Wolfgang. Research Assistant, Mathematical Institute, University of Göttingen. The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Wolfgang. The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxicity. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0. This file contains the Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. Link Wolfgang Dr. Möchten Sie Link Wolfgang Dr. in Göttingen-Groß Ellershausen anrufen? November 1940 in Ludwigshafen; † 7. two unstructured segments. Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. Traditional force spectroscopy of titin can study only eight tandem Ig domains at a time, and the dominant English, German. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. MPS develops and builds scientific instruments that investigate solar system bodies. Es gibt 30+ Personen namens „Wolfgang Link“, die LinkedIn zum Austausch von Informationen, Ideen und Karrierechancen nutzen. Max Planck Institute for Solar System Research. The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Jede Zelle besitzt ein verzweigtes Netzwerk von... Muskelkraft und -bewegung beruhen auf molekularen Prozessen in den kontraktilen Bausteinen der Muskelzellen, den Sarkomeren. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. Dort liegen die Eiweiße Myosin und Aktin als Myofilamente vor. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. Cuvillier Göttingen (in Zusammenarbeit mit. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in human heart, resulted in impaired autophagy, heart failure, and shortened lifespan. Wolfgang Victor Ruttkowski is a scholar of literature and culture. Aims: The heart is constantly challenged with acute bouts of stretching or overload. TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. Webseiten der Georg-August-Universität Göttingen. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Here, we describe a mouse model in which Z-disc-anchored TTN is depleted in adult skeletal muscles. To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Imbalances in protein homeostasis caused by mutant desmin, 234th ENMC International Workshop: Chaperone dysfunction in muscle disease, December 8-10th 2017, Naarden, Netherlands, A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance. Highlights Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). We investigated newly generated immortalized heterozygous and homozygous R349P desmin knock‐in myoblasts in conjunction with the corresponding desminopathy mice as models for desminopathies to analyse major protein quality control processes in response to the presence of R349P mutant desmin. The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Small heat shock proteins such as alphaB-crystallin (aBC) translocate under physiological or pathological stress to the titin springs. Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.A copy of the license is included in the section entitled GNU Free Documentation License. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against... Background: The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. agric. Er leitete von 1977 bis 2014 das Institut für Humangenetik der Medizinischen Fakultät der Universität Göttingen. E-Mail: dialog@vobakg.de . While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contr... Reversible post-translational modifications of various cardiac proteins regulate the mechanical properties of the cardiomyocytes and thus modulate the contractile performance of the heart. Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen Zenker Ofenbackform Auflaufform mit Buch Low-Carb-Aufläufe von Wolfgang Link Mit dem 2-teiligen Set mit Ofenbackform und Low-Carb-Aufläufe Buch von Zenker können sie nicht nur tolle Rezepte nachkochen, sondern können auch noch Ihrer Traumfigur ein Stückchen näherkommen. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. Objective: In the Western countries cardiovascular disease and cancer are the leading causes of death in the ageing population. In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . We used hetero‐ and homozygous R349P desmin... Background Richtige Adressen und Telefonnummern finden! Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Universität Göttingen. nat., University of Göttingen. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. A personal tribute to Johann Caspar Rüegg (1930–2018): milestones of muscle research, JACBTS Gotzmann Linke Published SupplFigure, Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis, Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1, Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo, P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities, Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening, Stretch-induced compliance: A novel adaptive biological mechanism following acute cardiac load, Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, Genetically Engineered Human Stem-Cell Derived Cardiomyocytes to Investigate the Function of Cronos Titin, Quantifying the Titin Contribution to Muscle Force Generation using a Novel Method to Specifically Cleave the Titin Springs in Situ, Supplementary Figures&Table Nat-Commun Revision Final corrected, Titin Truncation Position Determines Propensity for Dilated Cardiomyopathy, Impaired Ventricular Relaxation and Passive Stiffness in Zebrafish, Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Placenta-Derived Adherent Stromal Cells Improve Diabetes Mellitus-Associated Left Ventricular Diastolic Performance: Placenta Stromal Cells and Diastolic Relaxation, Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function, Supplementary Figure S1 for Unger et al., Acta Neuropathol Commun. Methods 1984: Dr. rer. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. Dahl salt-sensitive (DSS) rats and control rats were fed... Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Universitätsmedizin Göttingen Klinik für Neurologie Robert-Koch-Straße 40 37075 Göttingen . Wolfgang A. Linke Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. 1 für Adressen und Telefonnummern Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Publications. Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and 1984 - 1989 Universities of Tübingen, Munich and Göttingen, law studies. März 1949 geboren. Accordingly, regulated protein decay is critical to maintain cardiac function. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. Due to our privacy policy, only current members can send messages to people on ResearchGate. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. PmtA catalyzes the successive three-step N -... Background:

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